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Natoli Scientific

Need help with tablet compression troubleshooting?

tablet press troubleshooting Natoli ScientificNatoli Scientific was founded to research new formulation techniques and tablet compression technology. We combine our four decades of experience with a network of university, consultant, and resident resources to investigate problems and offer our customers unique solutions to their product formulation and tooling requirements. Using the correct tablet tooling selection, tool steel, tool coating, and die configurations is crucial in combating common tableting problems such as sticking, picking, capping, lamination, and tool binding. Our goal is to modify configurations before larger problems arise and you lose more time and money.

By teaming up with Natoli Scientific, you’ll combine your resources with ours to troubleshoot the issues you’re having. Working closely with the Academic Research Consortium, we conduct designed experiments at Natoli Institute facilities and bring you straightforward solutions that actually work.

Natoli Institute for Industrial Pharmacy Research and Development


We established the Natoli Institute for Industrial Pharmacy Research and Development with the Arnold and Marie Schwartz College of Pharmacy and Health Sciences at Long Island University (LIU) to offer formulation assessments and research. We conduct formulation assessments for our customers at these facilities that would be difficult to do elsewhere. We are lucky to be able to offer such a troubleshooting solution and use this partnership to research new formulation techniques and technology.

Our staff has the knowledge to assess and resolve your most pervasive problems

Whether your questions can be resolved in our on-campus laboratory, or at the Natoli Engineering Institute for Industrial Pharmacy Research and Development, our experienced staff can help. If your problem is a common one, our staff can provide immediate assistance and have your tablet tooling back to normal in no time. If your issue needs more research, you can be sure we’ll get you the answers you need.

Natoli Scientific’s Research & Development Laboratory


Natoli Scientific’s laboratory facility in Telford, Pennsylvania, enables our researchers to evaluate and characterize the mechanical properties of formulations using a full range of lab-scale R&D and production tablet presses, dry and wet granulation machines, a compaction emulator, and coating equipment. Our contract research services can address each element of product development and help prepare you to meet GMP standards when your formulation goes into production.

Our tablet development contract services include:

  • Formulation evaluation for sticking and picking problems
  • Formulation evaluation for tool steel and coating recommendations
  • Formulation modification to improve tableting and performance in the tablet press
  • Investigation of tool steel failure
  • Recommendations on coatings for abrasive and corrosive formulations

The Pennsylvania facility also offers tablet manufacturing process training in classroom and hands-on learning environments. Natoli Scientific classes help those involved with research and development gain an overview of granulation principles and best practices; learn about common excipients and their designed functions; understand the factors that can influence successful tablet coating; and learn the importance of characterization, measurement, blending, and more.

No request is too large or too small — use the form below to contact us now and you’ll be happy you did.