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Natoli Engineering NP-P20A Tableting Press Machine


Designed for Small Scale Production

Natoli Engineering’s NP-P20A single-station hydraulic tablet press is a favorite for the production of injectable micro-pellets and for marginal formulations requiring deep-fill. The NP-P20A meets the FDA’s requirements for batch reporting and secure data management under CFR 21 Part 11 compliance. Get a quote today.

Formulation Fill Options:

Standard Fill: Produces standard-sized tablets from formulations that are capable of consistently filling the dies.
Shaker Fill: Enables inject-able micro-pellets to be produced vertically even with product formulations whose characteristics will not fill the die consistently.
Deep-Fill: Provides the fill depth to make very thick tablets and inject-able micro-pellets vertically even in higher dosages.
Double-Fill: Produces tablets that require more fill depth than allowed with the deep-fill option.
Pre-compression: Eliminates air entrapment to prevent capping and lamination and can be run simultaneously with other operating modes.


  • Easy-to-use menu-driven operation
  • Intuitive 12″ HMI touchscreen
  • Mobile press with four casters
  • Utilizes standard TSM and EU B, D, core rod, deep-fill, and multi-tip tooling. Tooling can be keyed or not keyed
  • Programmable parameters for pre- and main compression force control
  • Completely enclosed guard system
  • Autodosing feature adjusts dosing to maintain compression force with product granulation density changes
  • Automatic ejection

  • Deep-fill B and D tooling option increases B or D tooling maximum depth of fill from 12.7 mm to 34.9 mm using special deep-fill tooling
  • Core rod B and D tooling
  • Large tablets with a major axis up to 50 mm can be produced in standard and unique shapes

Natoli AIM™ Control System:

Provides all the reporting and features of a full-size production rotary tablet press – modified to a single-station configuration.

Audit Trail Module: Records all critical setting changes during batch production.

Recipe Module: Reduces set-up time by storing product recipes in a secure database.

Batch Reporting Module: Records and stores all batch records, alarms, errors, stops, and starts. This information can be extracted to a USB drive or automatically saved to a secure network drive.

Security Module: Has five levels of security based on job function. Authentication and accessibility to different modules can be managed at the console or from a remote connection. Optional authentication using an HID badge can be added.

Remote Module: Provides a secure connection so settings and critical production data can be monitored remotely from a desktop PC. Natoli engineers can troubleshoot issues, monitor performance, and install software upgrades remotely after hours if required.


Key Benefits:

  • Consistent Pellet/Tablet Thickness: Both upper and lower punch positions are adjusted at maximum compression to ensure consistency of tablet/pellet thickness, a critical dimension for inject-able therapies.
  • Rejects Defective Tablets: User-programmable tablet rejection system automatically identifies and rejects tablets based on compression force changes and the position of the upper and lower punches at maximum compression.
  • Consistent Weight Control: Feeder paddle speed and fill time of the die are adjustable, allowing even hard-to-tablet products to be produced at a consistent weight.


Station Count 1 1 1 1 1
Punch Type EU 19 / TSM B EU 1″ / TSM B EU 1″ / TSM D Deep Fill D Deep Fill B
Die Type B BB D Special Special
Max. Depth of Fill 20.6 mm (0.8110″) 17.5 mm (0.6875″) 22.2 mm (0.8740″) 12.7—34.9 mm (0.5000—1.3740″) 12.7—34.9 mm (0.5000—1.3740”)
Max. Round Diameter 17.5 mm (0.6875”) 16.0 mm (0.6299″) 23.8 mm (0.9370″) 23.8 mm (0.9370″) 17.5 mm (0.6875”)
Shaped Major Dimension 19.1 mm (0.7519″) 16.0 mm (0.6299”) 25.4 mm (1.00″) 25.4 mm (1.00″) 19.1 mm (0.7519″)
Max. Main Compression Force 42 kN / 9,500 lbs
Max. Pre-Compression Force 42 kN / 9,500 lbs
Tablet Rate Per Hour 120
Weight 500 kg / 1100 lbs
Shipping Weight 680 kg / 1500 lbs
Power Requirements 110-230VAC 1ph 50-60hz 24 amps



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Thank you so much for getting the tooling done so quickly.  As I was telling my client, I had a great relationship with Natoli in the past at my previous employer and Natoli will always go above and beyond to try to help the client out but even I was surprised that you could turn around this order so quickly.  From our management, we really appreciated Natoli being able to process the tooling in an expedited manner!!!!

- a Pharmaceutical Company