USP 1062 – Natoli

Intro to USP <1062> – What it is and Why You Should Use it

There are a variety of factors like powder flow, material characteristics, compression pressure, turret speed, etc. that can affect the quality of the tablets and production run time. Any resulting tablet defects can exacerbate production costs, or even worse: result in no product at all! Therefore, it is necessary to characterize the tablet compression process… Read More

Intro to USP <1062> — What is Tabletability?

It is hard enough to create a successful tablet. But making one that’s robust enough to survive the journey from manufacturing to packaging is another undertaking entirely. And if overlooked, it could result in a tarnished brand reputation at best, and patients taking inaccurate dosages at worst. During this journey, tablets may turn, tumble, chip,… Read More

Impact of Punch Cup Depths on USP <1062> Profiles and Capping Index

USP <1062> tablet characterization is one of the most integral chapters to understanding the tablet characterization process; it helps to understand the compactibility, tabletability, and compressibility of the material. USP <1062> profiles are impacted by any adjustments to the material and tablet tooling. In the present study, Natoli has mainly focused on the impact of… Read More

Closing The ‘Knowing-Doing’ Gap In R&D Using USP <1062> Data

One of the most rewarding things about being a science technician is being able to easily measure your impact. And for many in the pharmaceutical industry today, measuring this impact begins with analytics. As an R&D scientist, accessing your analytics is essential to determining whether your formulation’s purpose can be realized, i.e. if the product’s… Read More

$Compression pressure, tensile strength, and solid fraction diagram$

Natoli Hosts First-of-its-Kind Training Seminar on USP <1062>

Five years ago, the U.S. Pharmacopeia (USP) published a general chapter <1062> on Tablet Compression Characterization. In simplest terms, USP general chapter <1062> provides direction for best practices as they relate to tablet compression test procedures. Despite the half-decade timeframe, very few companies have made an intentional effort to instruct R&D scientists on how… Read More