by Robert Sedlock, Director, Natoli Scientific The tablet manufacturing process has many challenges. An understanding of the steps leading up to the final compressed tablet is crucial to the task of producing a high-quality tablet. The final tablet weight is a direct response of the volumetric filling of the die during the tableting process. Thus,… Read More
Manufacturers use tablet presses to produce a variety of products, such as pharmaceuticals, nutraceuticals, veterinary products, confectionary products, and industrial tablets. Each industry faces unique challenges depending on the properties inherent to the formulations that industry uses. A variety of steel types and coatings, tool-design modifications and options, and tablet designs can work together to… Read More
Rushing A Product to Market Can Yield Some Expensive and Painful Lessons When scaling a new drug formulation from development into manufacturing, there is often a reality check regarding process scale-up and formulation performance at production levels. Problems with capping/lamination and sticking/picking are often first realized when a formulation is introduced to a level of… Read More
This article originally ran in the October 2018 issue of European Pharmaceutical Manufacturer magazine. By Jonathan Gaik, Natoli Scientific Tablet formulation development is a stylised process. Each formulator uses their own methodology. Some use the systematic Design of Experiments (DOE) approach, some test one variable at a time, and many use a combination of the two. However, all… Read More
In the July/August 2018 issue of EPM magazine, we wrote that most challenges in the tableting process begin with, or can be traced back to, powder flow. We mentioned in our article. In our article, we mentioned that conducting studies on a formulation in the R&D stage, and later in scale-up, can help identify and… Read More
This article originally ran in the July/August 2018 issue of European Pharmaceutical Manufacturer magazine. By Jonathan Gaik, Natoli Scientific The ideal active pharmaceutical ingredient (API) is one that flows well, is stable, self-lubricates, compacts well and is not strain rate sensitive. While all the listed properties are important, the one that continues to be critical… Read More
Multi-tip punches are a cost-effective means of increasing tablet output without adding additional tablet presses. Multi-tip punches follow a similar principle as a single tip tool for the rotary tablet press, but operating techniques differ. Two common multi-tip tool configurations for B and D tooling are assembled and solid type tools. When choosing which configuration best fits… Read More
This post shares content from an article in Contract Pharma. Click here for the full article. The pharmaceutical industry has seen a number of changes in the more than 40 years Natoli Engineering has been a major manufacturer of tablet compression tooling. From medical advances to the continued growing trend to outsource pharmaceutical manufacturing, the solid dose… Read More
This article originally published in Tablets and Capsules’ “Solid Dose Digest” sent July 25, 2016. Industry experts have long debated the best tooling for tablet manufacturing. To understand why their opinions differ, you must first understand the history of the punch. In this edition of the column, I show that the standard head flat has… Read More
For a number of years the buzz around continuous manufacturing as the next big leap in pharmaceutical manufacturing has grown. From companies looking for greater efficiency in their processes to governmental regulations enacting changes, the tableting industry has been working hard on solving this puzzle. While the theories of how a company can enact these… Read More
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I have incredible respect for the people at Natoli. They are great people that are truly passionate about their work…I respect your work and values. Especially seeing the quality of your tools, presses, and the overall diversity of workers at Natoli.
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