by Robert Sedlock, Director, Natoli Scientific The tablet manufacturing process has many challenges. An understanding of the steps leading up to the final compressed tablet is crucial to the task of producing a high-quality tablet. The final tablet weight is a direct response of the volumetric filling of the die during the tableting process. Thus,… Read More
Natoli had multiple representatives sharing their expertise with the several hundred people who tapped in to view this live online event. Virtual Pharma Expo presentation on Multi-Tip Tooling by Bill Turner In this presentation, Bill Turner discusses the advantages of using multi-tip tooling. He presents that to reduce your overall operating costs you must increase… Read More
Q: How do we determine the cause of tablet capping during production and prevent it from occurring? A: Robert Sedlock, Natoli Engineering, says: The term capping in tablet manufacturing refers to a tablet failure, a break across the horizontal plane, that you find when performing a breaking force or friability test. Many factors can contribute to… Read More
Q: What’s the proper way to maintain my tablet presses and tooling? A: Stephen Natoli says: Many factors can reduce the life expectancy of tooling and tablet presses, such as abrasive or corrosive formulations, press or turret wear, improper tooling setup on the press, and mishandling of tooling by technicians. Creating and following a tooling… Read More
Rushing A Product to Market Can Yield Some Expensive and Painful Lessons When scaling a new drug formulation from development into manufacturing, there is often a reality check regarding process scale-up and formulation performance at production levels. Problems with capping/lamination and sticking/picking are often first realized when a formulation is introduced to a level of… Read More
The number one reason for tablet press failure is lack of tooling cleanliness. Dirty tooling may cause binding, which can damage tooling and tablet presses. Keeping tools clean can decrease premature tool wear and allow lubrication to be more effective as well as reduce the possibility of product cross-contamination. Additionally, clean tooling is critical to… Read More
Tablet compression tooling is a considerable investment for your company. Quality tooling and a proper maintenance routine are critical for efficiently producing high-quality tablets. Polishing is one of the most inexpensive ways to maintain tablet quality, reduce production-related costs, and decrease tablet-press downtime. Punches and dies experience wear during tablet production, this can lead to tooling… Read More
In the October 22, 2018, issue of Solid Dose Digest, a reader asked, “I need tablet compression training. How do I decide which course is right for me?” Natoli Scientific Director Jonathan Gaik answered: Tablet compression is complicated, and most who work in the industry learn on the job, but a growing number of options… Read More
Sticking and picking are ubiquitous problems in tablet manufacturing and generally arise from either formulation or tablet design inadequacies. Sticking occurs when formulation granules stick to the face of the punch cup. Formulation sticking in the letters and characters of punch embossing is typically referred to as picking. Both result in tablet defects and lower… Read More
By Jonathan Gaik, Director, Natoli Scientific In the July/August issue of EPM magazine, I wrote that most challenges in the tableting process initiate with or can be traced back to powder flow. I mentioned in my article – “Go with the flow: The critical issue of powder flow in tablet production” – that conducting studies… Read More
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