Sticking and picking are ubiquitous problems in tablet manufacturing and generally arise from either formulation or tablet design inadequacies. Sticking occurs when formulation granules stick to the face of the punch cup. Formulation sticking in the letters and characters of punch embossing is typically referred to as picking. Both result in tablet defects and lower… Read More
In the July/August 2018 issue of EPM magazine, we wrote that most challenges in the tableting process begin with, or can be traced back to, powder flow. We mentioned in our article. In our article, we mentioned that conducting studies on a formulation in the R&D stage, and later in scale-up, can help identify and… Read More
This article originally ran in the July/August 2018 issue of European Pharmaceutical Manufacturer magazine. By Jonathan Gaik, Natoli Scientific The ideal active pharmaceutical ingredient (API) is one that flows well, is stable, self-lubricates, compacts well and is not strain rate sensitive. While all the listed properties are important, the one that continues to be critical… Read More
First impressions are everything, especially for pharmaceutical, nutritional, and confectionery tablets. Discriminating consumers may decide whether they will be repeat customers based on a tablet’s appearance and their experience. That’s why tablet design should not be overlooked or taken for granted. Much too often in our industry, we see poor tablet design holding back companies. Don’t… Read More
As the global leader in tablet compression tooling, we custom engineer and craft a wide range of precision multi-tip tooling in various configurations to your exact specifications. Multi-tip tooling significantly increases tablet production without adding a new tablet press or additional space and labor. It also: Reduces press run time with higher production levels Dramatically cuts operating… Read More
The principal purpose for capsule segment alignment is to allow the capsules to be separated reliably and rejoined accurately. To do this, the hole in the upper segment must be accurately lined up with the lower segment, and the segment surfaces must be parallel. Before Aligning Segments Before aligning segments, the lower segment is placed… Read More
You’ve tried every trick in the book and nothing seems to fix your sticking and picking issues. At Natoli Engineering, we’ve done our homework. Our tablet and tooling experts find and fix tableting troubles every day. Using real-world knowledge and technical data, we’ll analyze issues to create real solutions for your problems. Whether you need… Read More
Dust cups are a low-cost solution that keep excess lubrication out of tablets, and bellows help reduce issues like tool binding by reducing friction by keeping formulation off tools. As tip-mounted dust cups require you to cut out a hole to install on punches, Natoli has developed our Dust Cup Cutter to make this process quick… Read More
Inspecting your turret is an essential part of regular press maintenance, and trying to inspect manually is nearly impossible. That’s why it is important to have a Certified Turret Inspection Kit specifically designed for your tablet press. Understanding how to use the kit is also crucial. Watch the video below and see how easy it… Read More
Multi-tip punches are a cost-effective means of increasing tablet output without adding additional tablet presses. Multi-tip punches follow a similar principle as a single tip tool for the rotary tablet press, but operating techniques differ. Two common multi-tip tool configurations for B and D tooling are assembled and solid type tools. When choosing which configuration best fits… Read More
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