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Compression pressure, tensile strength, and solid fraction diagram

Natoli Hosts First-of-its-Kind Training Seminar on USP <1062>

  Five years ago, the U.S. Pharmacopeia (USP) published a general chapter <1062> on Tablet Compression Characterization. In simplest terms, USP general chapter <1062> provides direction for best practices as they relate to tablet compression test procedures. Despite the half-decade timeframe, very few companies have made an intentional effort to instruct R&D scientists on how… Read More

Powder Rheology: Gateway For Tablet Sticking Insights

Authors: Devang Patel, Kerry Cruz, Robert Sedlock, Rahul Haware A tablet is the product of the right marriage between pharmaceutical materials and manufacturing conditions. Proper pharmaceutical blend properties are a major contributor of this success. Though pharmaceutical tablets have enjoyed their place on the pharmacy shelves for centuries, their development is prevalently based on trial… Read More

Rotary Tablet Press Cycle

Powder Die Filling Is Essential To Produce Quality Tablets

  by Robert Sedlock, Director, Natoli Scientific The tablet manufacturing process has many challenges. An understanding of the steps leading up to the final compressed tablet is crucial to the task of producing a high-quality tablet. The final tablet weight is a direct response of the volumetric filling of the die during the tableting process. Thus,… Read More

Webinar Image for Natoli Engineering's Tablet & Pill Press Training

Natoli Scientific Webinar Series

Throughout the month of February, the team at Natoli Scientific, along with industry experts from Granutools, Alexanderwerk, and Long Island University, presented several webinars covering tablet development, as well as wet and dry granulation techniques. A comparative study was performed using three levels of Acetaminophen active in a tablet formulation. Powder flow, compactability, and scalability was… Read More

Natoli Scientific Training Course Instructors Include Industry Thought Leaders

Earlier this month, the Natoli Scientific R&D Laboratory in Telford, Pennsylvania presented a training course on the tablet development process and the basic principles of continuous manufacturing. Course instruction was provided by thought-leaders from the pharmaceutical manufacturing industry as well as members of the Natoli Scientific technical training staff. In addition to the educational presentations… Read More

Attendees Reviewing Tablet Press Process

Natoli Scientific Telford, PA Lab Hosts Tablet Development Process and Continuous Manufacturing Training Course

The newly opened Natoli Scientific R&D Laboratory in Telford, PA recently held a one-day training course focusing on the tablet development process and the basic principles of continuous manufacturing. This course gave trainees a first-hand look into tablet development and formulation in a unique laboratory environment. Following the conclusion of the training session, one participant… Read More

Natoli Shares Knowledge at University of Maryland

Robert Sedlock, Director of Technical Training & Development at Natoli Scientific, taught a module on tablet compaction for a short course at the University of Maryland School of Pharmacy. The course, Tablets & Capsules Hands-On Short Course, took place October 15-19, 2018. Robert’s lecture taught course participants about powder compression, tablet press operation, test methods for formulation development, and compaction… Read More

Telford Lab Launches with Successful Formulation Development Training

Natoli Scientific’s new Telford, Pennsylvania, R&D laboratory opened its doors with the inaugural “Formulation Development, Scale-up, and Intro to Microtabs” training October 8-10, 2018. Seventeen attendees from the pharma, specialty chemicals, nutritional supplements, and pyrotechnics industries helped us kick off activities in our new facility. Taught by industry-leading experts, our attendees learned new approaches to formulation… Read More

Do you need help with tablet compression troubleshooting?

Natoli Scientific was founded to research new formulation techniques and tablet compression technology. We combine our four decades of experience with a network of university, consultant, and resident resources to investigate problems and offer our customers unique solutions to their product formulation and tooling requirements. Using the correct tablet tooling selection, tool steel, tool coating,… Read More

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