There are a variety of factors like powder flow, material characteristics, compression pressure, turret speed, etc. that can affect the quality of the tablets and production run time. Any resulting tablet defects can exacerbate production costs, or even worse: result in no product at all! Therefore, it is necessary to characterize the tablet compression process… Read More
It is hard enough to create a successful tablet. But making one that’s robust enough to survive the journey from manufacturing to packaging is another undertaking entirely. And if overlooked, it could result in a tarnished brand reputation at best, and patients taking inaccurate dosages at worst. During this journey, tablets may turn, tumble, chip,… Read More
In the tablet compression industry, we widely regarded USP Chapter <1062> as the one chapter that any R&D Scientist should be familiar with as they develop new formulations. This Chapter describes the relationship between a tablet’s compactibility, compressibility, tabletability, and manufacturability. But what about encapsulation? Capsule filling machines differ greatly from rotary tablet presses. There… Read More
USP <1062> tablet characterization is one of the most integral chapters to understanding the tablet characterization process; it helps to understand the compactibility, tabletability, and compressibility of the material. USP <1062> profiles are impacted by any adjustments to the material and tablet tooling. In the present study, Natoli has mainly focused on the impact of… Read More
One of the most rewarding things about being a science technician is being able to easily measure your impact. And for many in the pharmaceutical industry today, measuring this impact begins with analytics. As an R&D scientist, accessing your analytics is essential to determining whether your formulation’s purpose can be realized, i.e. if the product’s… Read More
Five years ago, the U.S. Pharmacopeia (USP) published a general chapter <1062> on Tablet Compression Characterization. In simplest terms, USP general chapter <1062> provides direction for best practices as they relate to tablet compression test procedures. Despite the half-decade timeframe, very few companies have made an intentional effort to instruct R&D scientists on how… Read More
A tablet is the product of the right marriage between pharmaceutical materials and manufacturing conditions. Proper pharmaceutical blend properties are a major contributor of this success. Though pharmaceutical tablets have enjoyed their place on the pharmacy shelves for centuries, their development is prevalently based on trial and error instead of a robust scientific approach. This… Read More
by Robert Sedlock, Director, Natoli Scientific The tablet manufacturing process has many challenges. An understanding of the steps leading up to the final compressed tablet is crucial to the task of producing a high-quality tablet. The final tablet weight is a direct response of the volumetric filling of the die during the tableting process. Thus,… Read More
The budding cannabis tablet industry can be very lucrative. Producing the tablets can seem like an overwhelming proposition. That’s why Natoli Engineering offers a two-day hands-on learning experience. Join us for our upcoming Cannabis Oil, Powder Processing & Tablet Manufacturing Process this June 13-14, 2023 in Telford, PA. This intensive course will provide you with the… Read More
Throughout the month of February, the team at Natoli Scientific, along with industry experts from Granutools, Alexanderwerk, and Long Island University, presented several webinars covering tablet development, as well as wet and dry granulation techniques. A comparative study was performed using three levels of Acetaminophen active in a tablet formulation. Powder flow, compactability, and scalability was… Read More
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