Tooling and press manufacturers are faced with ongoing challenges in the tablet manufacture environments. Providing support in all aspects of the compression process should be expected from your partnering vendor. These services should include press operator training, maintenance /calibration services, quick delivery parts, tooling / tablet design and powder formulation support. When compression issues occur the above services are available to support your challenges but a change in the formulation requires a process following SUPAC (Scale-Up and Post Approval Changes) guidelines which can be time consuming and halt manufacturing. This article will describe the importance of the formulation development process and how a thorough approach can reduce manufacturing issues, costs and downtime. The case studies provided in this article were performed at the Natoli Institute for Industrial Pharmacy Research & Development – Arnold and Marie Schwartz College of Pharmacy and Health Sciences on the Brooklyn, NY campus of Long Island University.
Developing a robust tablet formulation that can be scaled into manufacturing without any issues can be a challenge. Formulators and research professionals alike are tasked with the development process and an understanding of the science involved with powder compaction and proper communication with the scale up or manufacturing group can accelerate the time to achieve a marketed product with a higher return on investment.
Single station tablet presses offer many advantages during early development. These machines require a very limited amount of material to characterize a potential formulation. The die filling process can be performed manually allowing the use of only a few milligrams. Characterizing just the API can also be performed on these machines allowing the scientist to select the appropriate excipients based off the results of the compacted API.
Figure 1 (below) is a tabletability profile performed on the NP-RD10A single station tablet press. This is an example of evaluating a high drug load directly compressible APAP formulation (DB) versus a wet granulated APAP formulation (WG).
Instead of collecting the data using compression force (kN) there is an advantage to normalize for the punch tip face area and utilize compaction pressure. With any new formulation the required compression force is based off the material properties and tablet size. Performing a compaction study from 50MPa – 300MPa covers the normal ranges for compressing pharmaceutical tablets of all sizes. Furthermore the tablet tensile strength is a normalization of the tablet geometry. Target hardness or a breaking force value (kilopond or Newtons) cannot be determined until further testing is performed. Target tensile strength of 1 -2MPa are representative values for a robust tablet that will withstand handling, friability and the coating operation.
The profile clearly shows that the wet granulation blend yields stronger tablets than the directly compressible blend throughout the compaction pressure ranges. Although there is a cost advantage with directly compressible blends as the equipment investment costs and process times are much lower. The next step in the process is to perform additional studies on a rotary tablet press.
Figure 2 (right) depicts the tabletability profile performed on the BLP 16 rotary tablet press at 20RPM turret speed for the DB and WG formulations. The BLP16 rotary tablet press is a 16 station B tooled machine that is capable of running at variable turret speeds.
It is clear that the profile shows different results as compared to the RD10A single station tablet press. This data is representative of what can be expected at the manufacturing level since the manufacturing machines utilize the rotary press design with upper and lower compression rollers. In this case the upper and lower punches are moving horizontally across the rollers and vertically to compress the powder where the single station machine only moves vertically for non-eccentric designs. This difference changes the dynamics of the compression event and has an impact to the final tablet attributes as shown in this example. Figure 3 (left) d
epicts the compaction profiles for the two different machines.
The WG formulation run on the BLP16 yields robust tablets above 1MPa tensile strength at a reasonable compaction pressure where the DB formulation exhibits capping above 100MPa of compaction pressure. It is clear that the WG blend is the choice formulation and that the BD blend will fail on a manufacturing rotary press.
Figure 4 (right below) are examples of different tabletability profiles. Profile a is an example of good tabletability, b is an example where tabletability is acceptable at lower compaction pressures but deteriorates at higher pressures and c is an example of poor tabletability.
Many factors can impact the tabletability curve including the powder deformation characteristics, particle size, shape, moisture content, amount of powder fines. Every product behaves differently on a tablet press even when run on a different day. Variation is due to changes in the properties of the raw materials, API, and excipients from batch to batch. This is why it is 
crucial that your product has a robust tabletability profile. Profile b is an example of where your tablet attributes might be acceptable at the research level or even scale up level but fails at the manufacturing level. Operating too close to the peak of the curve or on the descending side does not give any flexibility to the press operator when issues are found and with the many variables as describe above this is crucial.
The use of pre compression can improve your tabletability profile as it de-aerates and consolidates the material before the main compression event but it is wise to save this tool as a back up when issues arise at the manufacturing level. Developing a robust formulation without pre compression will allow the manufacturing press operators to make press adjustments to solve these issues.
Another study that is valuable in the development process is a strain rate study, where the compaction pressure is held constant and in this case we choose 150MPa since tablets were robust at this level, the turret speed is incrementally increased and tablet attributes were evaluated.
Instead of evaluating tablet strengths at different turret speeds it is a more scalable approach to normalize for the turret pitch circle diameter, punch head flat diameter and evaluate the tablet strengths as a function of dwell time which is the time under maximum compression force or when the punches are no longer moving vertically. Another important parameter to consider for press scalability is the punch vertical velocity or loading rate and the decompression event.
In figure 4 (left) we can observe that this WG formulation is not strain rate sensitive at dwell times as low as 13 milliseconds. Ultimately the product will be produced on a high speed manufacturing press and the dwell times can be calculated and further studies can be performed at the research level. As most research presses are designed with smaller diameter turrets, reaching similar velocities as the manufacturing machines cannot be achieved so your tooling head profile can be designed to simulate similar dwell times.
The methods above are ways to evaluate your potential formulations tabletability and scalability but we have not discussed how the ingredients that make up the formulation impact the final tablet quality. Apart from the tablet’s active ingredient, other essential components include diluents, binders, disintegrants, lubricants, glidants, coloring agents and more. This next section will describe the importance of powdered lubrication (i.e. Magnesium Stearate) and the negative effects with excessive amounts.
Lubricants are essential for successful tablet manufacture. They provide a means to reduce the friction at the interface between a tablet’s surface and the die wall during the tablet ejection event. High ejection forces and excessive friction can cause premature wear to the lower punch heads and press cam tracks, visual striations on the tablet belly band surface and lamination. Lubricants can also improve flowability as is reduces the inter-particle friction. With the many benefits of adding lubricant there are negative effects when the amounts are excessive and not optimized. An excessive amount of lubricant can cause tablet strength issues, increased disintegration and dissolution times and with the tablet press paddle feeder this issue can be exacerbated when feeder speeds are too high. The feeders could potentially over blend the formulation causing the lubricant to coat more particles inhibiting the bonding process during compression. As lubricants are hydrophobic in nature it will prevent the penetration of fluids hence the disintegration and dissolution issues. Furthermore when the tablet press is not set up properly and the selected fill cam is not appropriate for the dosing cam setting the excessive scrape off material is recycled back into the feeder for further mixing.
A lubricant study in the development process with varying amounts of lubricant will identify the optimum level. During a compaction profile study as described earlier the ejection force can be recorded as the applied compression force is incrementally increased. Since the ejection force is the product of the residual radial die force and the coefficient of friction between the tablet belly band and die wall the ejection force should increase with increased compression. If the ejection force does not increase with increased compression then the friction is reduced indicating that the lubricant level can be decreased. Furthermore, a properly designed ejection transducer is required to accurately measure the ejection event. As most tablet presses adjust the lower roller position to change compression force and tablet thickness the lower punch head will contact the ejection cam at a different location depending on the setting. A full travel transducer design is 
insensitive to punch position where a button load cell design is only accurate at one contact point. Figure 6 (left) is an illustration of the ejection event. This example adds another variable where the die has an excessive wear ring resulting in higher ejection forces and tablet quality issues.
Conclusion
With the many challenges in the pharmaceutical manufacturing world today, tooling and press manufactures are your key partners in the support of delivering a quality product. Tablet manufacturing issues arise from many variables including operator training, calibration and maintenance of equipment and the formulation that is compressed. It is crucial in the development process to optimize the formulation and evaluate tablet robustness from tabletability and scalability studies. This will help minimize the challenges faced at the manufacturing level and will allow the press operators to make press adjustments when the many variables arise unexpectedly.
