skip to main content

Impact of Punch Cup Depths on USP <1062> Profiles and Capping Index

USP <1062> tablet characterization is one of the most integral chapters to understanding the tablet characterization process; it helps to understand the compactibility, tabletability, and compressibility of the material. USP <1062> profiles are impacted by any adjustments to the material and tablet tooling. In the present study, Natoli has mainly focused on the impact of… Read More

Natoli’s G.A.S. Program Helps Employees Reduce Cost of Commute

Inflation. Bear markets. International conflicts. Fuel supply shortages. In today’s economic climate, we could cut the tension with a plastic knife. Those who are employed are facing a cost-of-living crisis, while their forward-thinking employers face an opportunity. On the tail of the Great Resignation, companies are looking for unique ways to show employees they can… Read More

image reads Gas Assistance Subsidy at the top, above a gas pump showing three dollars per gallon.

FOX News Interviews Natoli About Employee G.A.S. Program

KTVI Channel FOX 2 news caught wind of our Gas Assistance Subsidy (G.A.S.) Program and wanted to hear more about it! They met with President and CEO, Dale Natoli, who explained why he felt it was necessary to implement the Program. “You know, this is our workforce and that makes a company,” said Natoli. “Without the… Read More

Impact of Punch Cup Depths on USP Graph

Closing The ‘Knowing-Doing’ Gap In R&D Using USP <1062> Data

One of the most rewarding things about being a science technician is being able to easily measure your impact. And for many in the pharmaceutical industry today, measuring this impact begins with analytics. As an R&D scientist, accessing your analytics is essential to determining whether your formulation’s purpose can be realized, i.e. if the product’s… Read More

student holding a natoli pill press pill

Natoli Inspires a New Generation of Workers: St. Charles County CAPS

Natoli hosted a class of local high school students today at our global headquarters in St. Charles, MO. A cohort of approximately 30 students from the St. Charles County CAPS (Center for Advanced Professional Studies) toured our facility, led by training instructors Dave Holleran, Bill Turner, and Doug Kirsch, learning the basics of tooling manufacturing…. Read More

Natoli to Host Social Mixer After 2022 Interphex Conference

Come have a drink on us while savoring a one-of-a-kind view of Times Square in the heart of New York City! On the evening of Wednesday, May 25th, 2022, Natoli will host a casual mixer for attendees of the Interphex conference. This event will provide an opportunity for industry professionals to socialize in a relaxed… Read More

Natoli Attends 2022 Excipient World Conference & Expo

The 2022 Excipient World Conference & Expo, held in Kissimmee, Florida was a success! This was the conference’s first production since the global pandemic in 2020, which required the expo to be cancelled. Natoli returned to the conference in full force with a poster presentation on the impact of punch cup depths on USP <1062> Profiles… Read More

Compression pressure, tensile strength, and solid fraction diagram

Natoli Hosts First-of-its-Kind Training Seminar on USP <1062>

  Five years ago, the U.S. Pharmacopeia (USP) published a general chapter <1062> on Tablet Compression Characterization. In simplest terms, USP general chapter <1062> provides direction for best practices as they relate to tablet compression test procedures. Despite the half-decade timeframe, very few companies have made an intentional effort to instruct R&D scientists on how… Read More


For quarterly tooling tips, special deals, industry news, and more!

Thank you very much for all of the help and patience with these sets of tooling, I know it has been difficult at some points with a lot of changes along the way. All of your work is much appreciated.

- a Pharmaceutical and Biopharmaceutical Company